It can be replaced at R1 which has a pentyl chain. The indole Main is substituted at R3 by using a carbonyl team that is also linked to a naphthalene moiety.
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JWH-018 and its N-dealkylated metabolite were present in little amounts, with hydroxylated N-dealkylated metabolites being the principal signal. This implies that hydroxylation occurs in the two the naphthalene and indole parts on the molecule. Human metabolites had been identical, Whilst most metabolism transpired on the indole ring and pentyl facet chain. The hydroxylated metabolites were thoroughly conjugated with glucuronide.
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As a complete agonist at the two the CB1 and CB2 cannabinoid receptors, this chemical compound is classified as an analgesic medication.
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